We are searching for topics and funders for the next Longitude Prize. This idea is a draft for discussion about one possible prize focus that we are exploring.
What is the problem? Clinical care remains reactive because conditions like dementia or Parkinson's are typically recognised only after irreversible brain damage has occurred. Current diagnostic tools cannot reliably forecast individual disease trajectories or the specific timing of symptom onset. Why does the solution contribute to solving this? Integrating longitudinal biological and digital signatures allows for a transition to proactive, personalised medicine. This technology would provide actionable predictions that can inform screening, guide personalised interventions, and ultimately delay or prevent the onset of neurodegenerative disorders Who is the prize awarded to? Awarded to the team that develops a precision forecasting system capable of predicting individual neurodegenerative risk and disease subtypes years before clinical symptoms appear - and providing actionable clinical recommendations on how to prevent them. Check out the other ideas
The best prize ideas are developed through extensive research and engagement with experts, stakeholders and people with lived experience of the problems they are focused on. We start with a first draft like the one above – then work to improve, refine and validate our thinking. If you are interested in sharing your expertise, or helping us secure funding for the next Longitude Prize, please reach out.